The present study investigated the therapeutic potential of combining tumor-treating fields (TTF), a novel
cancer treatment modality that employs low-intensity, alternating electric fields, with 5-fluorouracil (5-FU), a standard chemotherapy drug used for treating pancreatic cancer. The HPAF-II and Mia-Paca II pancreatic cancer cell
lines were treated with TTF, 5-FU, or their combination. Combination treatment produced a significantly greater
inhibitory effect on cancer cell proliferation than each single modality. Furthermore, combination therapy induced a
substantially higher rate of pancreatic cancer cell apoptosis and exhibited a synergistic effect in clonogenic assays.
Additionally, combination treatment showed a greater inhibition of cancer cell migration and invasion than either
TTF or 5-FU alone. In conclusion, these findings suggest that the synergistic properties of TTF and 5-FU result in
greater therapeutic efficacy against pancreatic cancer cells than either modality alone and may improve survival
rates in patients with pancreatic cancer.
Yunhui Jo
Institute of Global Health Technology (IGHT), Korea University, Seoul 02841, Republic of Korea
Eunjun Lee, Geon Oh, Yongha Gi, Myonggeun Yoon
Department
of Bio-Medical Engineering, Korea University, Seoul 02841, Republic of Korea
Myonggeun Yoon
FieldCure Ltd., Seoul 02852,
Republic of Korea
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