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작성일 : 23-05-16 16:24
Potential prognostic factor in alternating electric fields therapy based on absorbed energy in tissue
 글쓴이 : 관리자
조회 : 671  

The present study aimed to determine a method for estimating a potential prognostic factor in alternating electric fields for the treatment of solid tumors based on cell survival curves that evaluate cell proliferation capability. In AGS, B16F10, U373, and HPAF-II cancer cell lines, the proportional relationships of the electric field magnitude and the duration of application with the proliferation of cancer cell lines was identified by in vitro alternating current electric field experiments performed under various conditions. A prognostic factor applicable to alternating electric field therapy was developed by identifying proportional relationships of the electric field magnitude and the duration of application with the proliferation of the four cancer cell lines. Through the experimental results, the absorbed energy in tissue has been suggested as a potential prognostic factor in alternating electric field therapy. The absorbed energy in tissue can be used as a reference to quantify the inhibition of cell proliferation related to control, enabling systematic assessment of alternating electric field therapy which, to date, has not been possible.

Geon Oh, Yongha Gi, Heehun Sung, Jaehyun Seo, Hyunwoo Kim

Department of Bioengineering, Korea University, Seoul 02841,Republic of Korea 

Yunhui Jo

Institute of Global Health Technology(IGHT), Korea University, Seoul 02841, Republic of Korea 

Jaemin Lee

Department of Internal Medicine, Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea 

Myonggeun Yoon

Department of Bioengineering, Korea University, Seoul 02841,Republic of Korea 

FieldCure Ltd.,Seoul 02852, Republic of Korea



AIPAdvances12,095311(2022)