Purpose:Tumor
treating fields (TTF) therapy is a noninvasive method that uses alternating
electric fields to treat various types of cancer. This study demonstrates the
combined effect of TTF and radiotherapy (RT) in vitro on pancreatic cancer,
which is known to be difficult to treat.
Materials and methods: In CFPAC-I and HPAF-II pancreatic cancer cell lines, the
combined in vitro effect of TTF and RT was evaluated by measuring cell counts,
markers of apoptosis, and clonogenic
cell survival. The
synergy effects were verified using
the Valeriote and Carpentier equations.
Results: TTF and RT
inhibited cancer cell growth more effectively than did mono therapy with TTF or
RT. The combined treatment also enhanced apoptosis more than mono therapy, as
shown by as says for cleaved poly (ADP-ribose) polymerase (PARP) and annexin V.
In addition, on the survival curve, this treatment method has been shown to work
synergistically.
Conclusion:These results suggest that combined treatment with
TTF and RT may be a good alter-native treatment for patients with pancreatic
cancer
Yunhui Jo
Department of Bio-convergence
Engineering, Korea University, Seoul, Korea
Geon Oh, Yongha Gi, Heehun Sung, Myonggeun
Yoon
Department of Bio-medical Engineering,
Korea University,Seoul, Korea
Eun Bin Joo, Suk Lee
Department of Radiation Oncology,
College of Medicine, Korea University, Seoul, Korea
INTERNATIONAL
JOURNAL OF RADIATION BIOLOGY2020, VOL. 96, NO. 12, 1528–1533
HOME > Research
조회 : 460
