작성일 : 23-05-16 13:22
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Evaluating direct and indirect effects of low-energy electronsusing Geant4-DNA
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글쓴이 :
관리자
 조회 : 391
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Monte
Carlo simulations can classify DNA damage into different types and predict the
amount of energy deposited. Geant4-DNA was used to predict simple and complex
DNA damage induced by irradiation of low-energy electrons at 0.1–50 keV. The
number of molecules generated at different energy levels of radiation was
analyzed after observing the gradual changes in the level of water radiolysis.
ADNA model was used to categorize direct damage according to the location of
strand breaks at the atomic level. The parameters of energy threshold (minimum
amount of energy needed to break DNA strands) and 10 base pairs (maximum
distance that separates two strand breaks) were set. All instances of water
radiolysis including the main OH radical occurred most frequently at 1 keV
followed by at 1.5 and 0.5 keV. Direct strand breaks most commonly occurred at
0.5 keV followed by at 0.3 keV. Finally, most of strand breaks occurred
more frequently at 0.5 keV than at 0.3 keV. The computational measure-ment
results for indirect and direct effects of irradiation depend on the type of
simulation code and the DNA model used. Values used in Geant4 (physics list,
chemical interaction time and energy threshold)may also influence the results.
Eunae Choi and Myong Geun Yoon
Department
of Bio Convergence Engineering, Korea University, Seongbuk-gu, Republic of
Korea
Kwon
Su Chon
Catholic University of Daegu, Gyeongsan, Republic
of Korea
RADIATION
EFFECTS & DEFECTS IN SOLIDS2020, VOL. 175, NOS. 11–12, 1042–1051 |
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